Cell Signaling Switches HOX-PBX Complexes from Repressors to Activators of Transcription Mediated by Histone Deacetylases and Histone Acetyltransferases

The Hoxb1 autoregulatory element comprises three HOX-PBX binding sites. Despite the presence of HOXB1 and PBX1, this enhancer fails to activate reporter gene expression in retinoic acid-treated P19 cell monolayers. Activation requires cell aggregation in addition to RA. This suggests that HOX-PBX co...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Saleh, Maya, Rambaldi, Isabel, Yang, Xiang-Jiao, Featherstone, Mark S.
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 2000
Fag:	Transcriptional Regulation
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102167/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11046157/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.22.8623-8633.2000
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