Recombinant Respiratory Syncytial Virus That Does Not Express the NS1 or M2-2 Protein Is Highly Attenuated and Immunogenic in Chimpanzees

Mutant recombinant respiratory syncytial viruses (RSV) which cannot express the NS1 and M2-2 proteins, designated rA2ΔNS1 and rA2ΔM2-2, respectively, were evaluated as live-attenuated RSV vaccines. The rA2ΔNS1 virus contains a large deletion that should have the advantageous property of genetic stab...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Teng, Michael N., Whitehead, Stephen S., Bermingham, Alison, St. Claire, Marisa, Elkins, William R., Murphy, Brian R., Collins, Peter L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Vaccines and Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102132/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10982380/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.19.9317-9321.2000
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