Intranasal Administration of 2/6-Rotavirus-Like Particles with Mutant Escherichia coli Heat-Labile Toxin (LT-R192G) Induces Antibody-Secreting Cell Responses but Not Protective Immunity in Gnotobiotic Pigs

We investigated the immunogenicity of recombinant double-layered rotavirus-like particle (2/6-VLPs) vaccines derived from simian SA11 or human (VP6) Wa and bovine RF (VP2) rotavirus strains. The 2/6-VLPs were administered to gnotobiotic pigs intranasally (i.n.) with a mutant Escherichia coli heat-la...

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Detalhes bibliográficos
Main Authors: Yuan, Lijuan, Geyer, Annelise, Hodgins, Douglas C., Fan, Zhiqian, Qian, Yuan, Chang, Kyeong-Ok, Crawford, Sue E., Parreño, Viviana, Ward, Lucy A., Estes, Mary K., Conner, Margaret E., Saif, Linda J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2000
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC102078/
https://ncbi.nlm.nih.gov/pubmed/10982326
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