Intranasal Administration of 2/6-Rotavirus-Like Particles with Mutant Escherichia coli Heat-Labile Toxin (LT-R192G) Induces Antibody-Secreting Cell Responses but Not Protective Immunity in Gnotobiotic Pigs

We investigated the immunogenicity of recombinant double-layered rotavirus-like particle (2/6-VLPs) vaccines derived from simian SA11 or human (VP6) Wa and bovine RF (VP2) rotavirus strains. The 2/6-VLPs were administered to gnotobiotic pigs intranasally (i.n.) with a mutant Escherichia coli heat-la...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Yuan, Lijuan, Geyer, Annelise, Hodgins, Douglas C., Fan, Zhiqian, Qian, Yuan, Chang, Kyeong-Ok, Crawford, Sue E., Parreño, Viviana, Ward, Lucy A., Estes, Mary K., Conner, Margaret E., Saif, Linda J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Vaccines and Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102078/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10982326/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.19.8843-8853.2000
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