The 60-Residue C-Terminal Region of the Single-Stranded DNA Binding Protein of Herpes Simplex Virus Type 1 Is Required for Cooperative DNA Binding

ICP8 is the major single-stranded DNA (ssDNA) binding protein of the herpes simplex virus type 1 and is required for the onset and maintenance of viral genomic replication. To identify regions responsible for the cooperative binding to ssDNA, several mutants of ICP8 have been characterized. Total re...

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Bibliographic Details
Main Authors: Mapelli, Marina, Mühleisen, Martin, Persico, Giorgia, van der Zandt, Hans, Tucker, Paul A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC102075/
https://ncbi.nlm.nih.gov/pubmed/10982323
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