Mutational Analysis of the Adeno-Associated Virus Type 2 (AAV2) Capsid Gene and Construction of AAV2 Vectors with Altered Tropism

Adeno-associated virus type 2 (AAV2) has proven to be a valuable vector for gene therapy. Characterization of the functional domains of the AAV capsid proteins can facilitate our understanding of viral tissue tropism, immunoreactivity, viral entry, and DNA packaging, all of which are important issue...

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Bibliografiske detaljer
Main Authors: Wu, Pei, Xiao, Wu, Conlon, Thomas, Hughes, Jeffrey, Agbandje-McKenna, Mavis, Ferkol, Thomas, Flotte, Terence, Muzyczka, Nicholas
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
Fag:
Gene Therapy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC102071/
https://ncbi.nlm.nih.gov/pubmed/10954565
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