Persistent Infection of Human Pancreatic Islets by Coxsackievirus B Is Associated with Alpha Interferon Synthesis in β Cells

The interactions of coxsackievirus B3 (CVB3), CVB4E2 (diabetogenic), and CVB4JBV (nondiabetogenic) strains with human pancreatic islets from eight adult brain-dead donors were investigated. Persistent replication of viruses in human islets was proved by detection of viral RNA by in situ hybridizatio...

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Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Chehadeh, Wassim, Kerr-Conte, Julie, Pattou, François, Alm, Gunar, Lefebvre, Jean, Wattré, Pierre, Hober, Didier
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2000
Schlagworte:	Pathogenesis and Immunity
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102054/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11024144/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.21.10153-10164.2000
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