Disrupting Surfaces of Nef Required for Downregulation of CD4 and for Enhancement of Virion Infectivity Attenuates Simian Immunodeficiency Virus Replication In Vivo

The multifunctional simian and human immunodeficiency virus (SIV and HIV) Nef proteins are important for virulence. We studied the importance of selected Nef functions using an SIV Nef with mutations in two regions that are required for CD4 downregulation. This Nef mutant is defective for downregula...

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Main Authors: Iafrate, A. John, Carl, Silke, Bronson, Scott, Stahl-Hennig, Christiane, Swigut, Tomek, Skowronski, Jacek, Kirchhoff, Frank
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2000
Teme:
Pathogenesis and Immunity
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC102020/
https://ncbi.nlm.nih.gov/pubmed/11024110
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