Cytocidal and Apoptotic Effects of the ClyA Protein from Escherichia coli on Primary and Cultured Monocytes and Macrophages

Cytolysin A (ClyA) is a newly discovered cytolytic protein of Escherichia coli K-12 that mediates a hemolytic phenotype. We show here that highly purified ClyA and ClyA-expressing E. coli were cytotoxic and apoptogenic to fresh as well as cultured human and murine monocytes/macrophages.

Saved in:
Bibliographic Details
Main Authors: Lai, Xin-He, Arencibia, Ignacio, Johansson, Anders, Wai, Sun Nyunt, Oscarsson, Jan, Kalfas, Sotos, Sundqvist, Karl-Gösta, Mizunoe, Yoshimitsu, Sjöstedt, Anders, Uhlin, Bernt Eric
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Molecular and Cellular Pathogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC101772/
https://ncbi.nlm.nih.gov/pubmed/10858262
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items