Potent Antipneumococcal Activity of Gemifloxacin Is Associated with Dual Targeting of Gyrase and Topoisomerase IV, an In Vivo Target Preference for Gyrase, and Enhanced Stabilization of Cleavable Complexes In Vitro

We investigated the roles of DNA gyrase and topoisomerase IV in determining the susceptibility of Streptococcus pneumoniae to gemifloxacin, a novel fluoroquinolone which is under development as an antipneumococcal drug. Gemifloxacin displayed potent activity against S. pneumoniae 7785 (MIC, 0.06 μg/...

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Publicat a:	Antimicrob Agents Chemother
Autors principals:	Heaton, Victoria J., Ambler, Jane E., Fisher, L. Mark
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 2000
Matèries:	Mechanisms of Action: Physiological Effects
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC101612/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11036032/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.11.3112-3117.2000
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