Potent Antipneumococcal Activity of Gemifloxacin Is Associated with Dual Targeting of Gyrase and Topoisomerase IV, an In Vivo Target Preference for Gyrase, and Enhanced Stabilization of Cleavable Complexes In Vitro

We investigated the roles of DNA gyrase and topoisomerase IV in determining the susceptibility of Streptococcus pneumoniae to gemifloxacin, a novel fluoroquinolone which is under development as an antipneumococcal drug. Gemifloxacin displayed potent activity against S. pneumoniae 7785 (MIC, 0.06 μg/...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Heaton, Victoria J., Ambler, Jane E., Fisher, L. Mark
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2000
Sujets:	Mechanisms of Action: Physiological Effects
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC101612/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11036032/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.11.3112-3117.2000
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