A Novel Action of the Proton Pump Inhibitor Rabeprazole and Its Thioether Derivative against the Motility of Helicobacter pylori

The motility of Helicobacter pylori was maximum at 37°C and at pH 6. A newly developed proton pump inhibitor, rabeprazole (RPZ), and its thioether derivative (RPZ-TH) markedly inhibited the motility of H. pylori. The concentrations of the drug necessary to inhibit 50% of the motility were 0.25, 16,...

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Hauptverfasser: Tsutsui, Nanako, Taneike, Ikue, Ohara, Tatsuki, Goshi, Satoshi, Kojio, Seiichi, Iwakura, Nobuhiro, Matsumaru, Hiroyuki, Wakisaka-Saito, Noriko, Zhang, Hui-Min, Yamamoto, Tatsuo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2000
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Mechanisms of Action: Physiological Effects
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC101604/
https://ncbi.nlm.nih.gov/pubmed/11036024
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