Fluoroquinolone Resistance in Clinical Isolates of Streptococcus pneumoniae: Contributions of Type II Topoisomerase Mutations and Efflux to Levels of Resistance

We report on amino acid substitutions in the quinolone resistance-determining region of type II topisomerases and the prevalence of reserpine-inhibited efflux for 70 clinical isolates of S. pneumoniae for which the ciprofloxacin MIC is ≥4 μg/ml and 28 isolates for which the ciprofloxacin MIC is ≤2 μ...

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Main Authors: Bast, Darrin J., Low, Donald E., Duncan, Carla L., Kilburn, Laurie, Mandell, Lionel A., Davidson, Ross J., de Azavedo, Joyce C. S.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2000
主題:
Mechanisms of Resistance
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC101601/
https://ncbi.nlm.nih.gov/pubmed/11036021
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