Purification and Characterization of a Cytotonic Protein Expressed In Vitro by the Live Cholera Vaccine Candidate CVD 103-HgR

Cholera vaccines developed by the deletion of CTX genes from Vibrio cholerae induce a residual reactogenicity in up to 10% of vaccinees. A novel cytotonic agent named secreted CHO cell elongating protein (S-CEP) was purified from culture supernatants of CVD 103-HgR (Levine et al., Lancet ii:467–470,...

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Main Authors: Sathyamoorthy, Venugopal, Hall, Robert H., McCardell, Barbara A., Kothary, Mahendra H., Ahn, Susie J., Ratnayake, Shashikala
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
Fag:
Molecular and Cellular Pathogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC101575/
https://ncbi.nlm.nih.gov/pubmed/10992523
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