Involvement of conserved histidine, lysine and tyrosine residues in the mechanism of DNA cleavage by the caspase-3 activated DNase CAD

The caspase-activated DNase (CAD) is involved in DNA degradation during apoptosis. Chemical modification of murine CAD with the lysine-specific reagent 2,4,6-trinitrobenzenesulphonic acid and the tyrosine-specific reagent N-acetylimidazole leads to inactivation of the nuclease, indicating that lysin...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Korn, Christian, Scholz, Sebastian Richard, Gimadutdinow, Oleg, Pingoud, Alfred, Meiss, Gregor
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 2002
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC101349/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11884629/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/30.6.1325
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