Interleukin-4 inhibits prostaglandin E2 production by freshly prepared adherent rheumatoid synovial cells via inhibition of biosynthesis and gene expression of cyclo-oxygenase II but not of cyclo-oxygenase I.

OBJECTIVE: To characterise the effect of interleukin-4 (IL-4) on the biosynthesis of cyclo-oxygenases I (COX I) and II (COX II), the rate limiting enzymes of the synthesis of prostaglandin E2 (PGE2), in freshly prepared rheumatoid synovial cells. METHODS: Adherent synovial cells were obtained from r...

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Hauptverfasser: Sugiyama, E, Taki, H, Kuroda, A, Mino, T, Yamashita, N, Kobayashi, M
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1996
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1010189/
https://ncbi.nlm.nih.gov/pubmed/8694577
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