Interleukin-4 inhibits prostaglandin E2 production by freshly prepared adherent rheumatoid synovial cells via inhibition of biosynthesis and gene expression of cyclo-oxygenase II but not of cyclo-oxygenase I.

OBJECTIVE: To characterise the effect of interleukin-4 (IL-4) on the biosynthesis of cyclo-oxygenases I (COX I) and II (COX II), the rate limiting enzymes of the synthesis of prostaglandin E2 (PGE2), in freshly prepared rheumatoid synovial cells. METHODS: Adherent synovial cells were obtained from r...

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Publicat a:Ann Rheum Dis
Autors principals: Sugiyama, E, Taki, H, Kuroda, A, Mino, T, Yamashita, N, Kobayashi, M
Format: Artigo
Idioma:Inglês
Publicat: BMJ Publishing Group 1996
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC1010189/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8694577/
https://ncbi.nlm.nih.govhttps://doi.org/10.1136/ard.55.6.375
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