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Activation of neutral metalloprotease in human osteoarthritic knee cartilage: evidence for degradation in the core protein of sulphated proteoglycan.

The neutral, metal dependent, proteoglycan degrading enzymes (NMPEs) in human osteoarthritic knee cartilage homogenates were activated by p-aminophenylmercuric acetate (APMA). The resultant effect on the structure of newly synthesised and already existing sulphated proteoglycan was measured. Newly s...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Martel-Pelletier, J, Pelletier, J P, Malemud, C J
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 1988
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC1003607/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3196082/
https://ncbi.nlm.nih.govhttps://doi.org/10.1136/ard.47.10.801
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