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Activation of neutral metalloprotease in human osteoarthritic knee cartilage: evidence for degradation in the core protein of sulphated proteoglycan.

The neutral, metal dependent, proteoglycan degrading enzymes (NMPEs) in human osteoarthritic knee cartilage homogenates were activated by p-aminophenylmercuric acetate (APMA). The resultant effect on the structure of newly synthesised and already existing sulphated proteoglycan was measured. Newly s...

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Bibliographische Detailangaben
Hauptverfasser: Martel-Pelletier, J, Pelletier, J P, Malemud, C J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1988
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1003607/
https://ncbi.nlm.nih.gov/pubmed/3196082
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