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Increased sensitivity of lymphocytes from patients with systemic autoimmune diseases to DNA alkylation by the methylating carcinogen N-methyl-N-nitrosourea.

Lymphocytes from patients with various diseases associated with autoimmunity showed both impaired capacity to repair O6-methylguanine (a powerful, promutagenic, directly miscoding base lesion) and increased sensitivity to the cytocidal effects of cellular methylation by N-methyl-N-nitrosourea (MNU)...

詳細記述

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書誌詳細
主要な著者: Lawley, P D, Topper, R, Denman, A M, Hylton, W, Hill, I D, Harris, G
フォーマット: Artigo
言語:Inglês
出版事項: 1988
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1003543/
https://ncbi.nlm.nih.gov/pubmed/3382263
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