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Mechanism for Mutational Inactivation of the Tumor Suppressor Smad2
Transforming growth factor β (TGF-β) is a potent natural antiproliferative agent that plays an important role in suppressing tumorigenicity. In numerous tumors, loss of TGF-β responsiveness is associated with inactivating mutations that can occur in components of this signaling pathway, such as the...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2001
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC100252/ https://ncbi.nlm.nih.gov/pubmed/11313456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.10.3302-3313.2001 |
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