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The TGF-β/Smad repressor TG-interacting factor 1 (TGIF1) plays a role in radiation-induced intestinal injury independently of a Smad signaling pathway.

Despite advances in radiation delivery protocols, exposure of normal tissues during the course of radiation therapy remains a limiting factor of cancer treatment. If the canonical TGF-β/Smad pathway has been extensively studied and implicated in the development of radiation damage in various organs,...

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Autori principali: Mohammad Hneino, Agnes François, Valerie Buard, Georges Tarlet, Rym Abderrahmani, Karl Blirando, Pamela A Hoodless, Marc Benderitter, Fabien Milliat
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2012-01-01
Serie:PLoS ONE
Accesso online:http://europepmc.org/articles/PMC3342305?pdf=render
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