Naturally Occurring Clostridium perfringens Nontoxic Alpha-Toxin Variant as a Potential Vaccine Candidate against Alpha-Toxin-Associated Diseases

Clostridium perfringens mutant strain 121A/91 shows neither enzymatic (phospholipase C) nor hemolytic activity. Nevertheless, the cpa gene and the corresponding alpha-toxin variant are detectable. Vaccination with this genetically constructed alpha-toxin variant, rAT121/91, induces antibodies capabl...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Schoepe, Heike, Pache, Christian, Neubauer, Axel, Potschka, Heidrun, Schlapp, Tobias, Wieler, Lothar H., Baljer, Georg
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2001
Assuntos:	Molecular Pathogenesis
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC100128/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11598102/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.69.11.7194-7196.2001
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