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Cytotoxic Necrotizing Factor from Escherichia coli Induces RhoA-Dependent Expression of the Cyclooxygenase-2 Gene

Cytotoxic necrotizing factor 1 (CNF) is a toxin produced by some isolates of Escherichia coli that cause extraintestinal infections. CNF can initiate signaling pathways that are mediated by the Rho family of small GTPases through a covalent modification that results in constitutive activation. In ad...

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Published in:Infect Immun
Main Authors: Thomas, Warren, Ascott, Zoe K., Harmey, Dympna, Slice, Lee W., Rozengurt, Enrique, Lax, Alistair J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2001
Subjects:
Molecular Pathogenesis
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC100062/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11598057/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.69.11.6839-6845.2001
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