Enhancement of Mycobacterium tuberculosis-Induced Tumor Necrosis Factor Alpha Production from Primary Human Monocytes by an Activated T-Cell Membrane-Mediated Mechanism

Mycobacterium tuberculosis alone induces small, donor-variable amounts of tumor necrosis factor alpha (TNF-α) from primary human monocytes in vitro. However, TNF-α release is increased 5- to 500-fold when fixed activated T cells (FAT) or their isolated, unfixed membranes are added to this system. Th...

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Main Authors: Warwick-Davies, Jan, Watson, Amanda J., Griffin, George E., Krishna, Sanjeev, Shattock, Robin J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Host Response and Inflammation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC100030/
https://ncbi.nlm.nih.gov/pubmed/11598025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.11.6580-6587.2001
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