E2F1 and E2F2 Determine Thresholds for Antigen-Induced T-Cell Proliferation and Suppress Tumorigenesis

E2F activity is critical for the control of the G(1) to S phase transition. We show that the combined loss of E2F1 and E2F2 results in profound effects on hematopoietic cell proliferation and differentiation, as well as increased tumorigenesis and decreased lymphocyte tolerance. The loss of E2F1 and...

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Autors principals: Zhu, Jing W., Field, Seth J., Gore, Lia, Thompson, Margaret, Yang, Haidi, Fujiwara, Yuko, Cardiff, Robert D., Greenberg, Michael, Orkin, Stuart H., DeGregori, James
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC100017/
https://ncbi.nlm.nih.gov/pubmed/11713289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.24.8547-8564.2001
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