E2F1 and E2F2 Determine Thresholds for Antigen-Induced T-Cell Proliferation and Suppress Tumorigenesis

E2F activity is critical for the control of the G(1) to S phase transition. We show that the combined loss of E2F1 and E2F2 results in profound effects on hematopoietic cell proliferation and differentiation, as well as increased tumorigenesis and decreased lymphocyte tolerance. The loss of E2F1 and...

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Detalhes bibliográficos
Main Authors: Zhu, Jing W., Field, Seth J., Gore, Lia, Thompson, Margaret, Yang, Haidi, Fujiwara, Yuko, Cardiff, Robert D., Greenberg, Michael, Orkin, Stuart H., DeGregori, James
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC100017/
https://ncbi.nlm.nih.gov/pubmed/11713289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.24.8547-8564.2001
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