C-Terminal Ubiquitination of p53 Contributes to Nuclear Export

The growth inhibitory functions of p53 are controlled in unstressed cells by rapid degradation of the p53 protein. One of the principal regulators of p53 stability is MDM2, a RING finger protein that functions as an E3 ligase to ubiquitinate p53. MDM2 promotes p53 nuclear export, and in this study,...

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Détails bibliographiques

Publié dans:	Mol Cell Biol
Auteurs principaux:	Lohrum, Marion A. E., Woods, Douglas B., Ludwig, Robert L., Bálint, Éva, Vousden, Karen H.
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 2001
Sujets:	Cell Growth and Development
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC100015/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11713287/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.24.8521-8532.2001
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