C-Terminal Ubiquitination of p53 Contributes to Nuclear Export

The growth inhibitory functions of p53 are controlled in unstressed cells by rapid degradation of the p53 protein. One of the principal regulators of p53 stability is MDM2, a RING finger protein that functions as an E3 ligase to ubiquitinate p53. MDM2 promotes p53 nuclear export, and in this study,...

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Detalhes bibliográficos
Main Authors: Lohrum, Marion A. E., Woods, Douglas B., Ludwig, Robert L., Bálint, Éva, Vousden, Karen H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2001
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC100015/
https://ncbi.nlm.nih.gov/pubmed/11713287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.24.8521-8532.2001
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