Harnessing MerTK agonism for targeted therapeutics

Phagocytosis plays important roles both in homeostasis and under pathological conditions. Fcγ receptor-mediated phagocytosis has been exploited as an integral mechanism for antibody-based therapies. Unlike Fcγ receptor-mediated phagocytosis, MerTK-mediated phagocytic clearance is immunologically sil...

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Autori principali: Vivekananda Kedage, Diego Ellerman, Yongmei Chen, Wei-Ching Liang, Joven Borneo, Yan Wu, Minhong Yan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis Group 2020-01-01
Serie:mAbs
Soggetti:
Phagocytosis
bispecific antibody
immunologically silent
MerTK
Fcγ receptor
Accesso online:https://www.tandfonline.com/doi/10.1080/19420862.2019.1685832
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