Synthesis, Anticancer Activity, and Preliminary Pharmacokinetic Evaluation of 4,4-Disubstituted Curcuminoid 2,2-bis(Hydroxymethyl)Propionate Derivatives

Compound <b>1</b> is a curcumin di-<i>O</i>-2,2-bis(hydroxymethyl)propionate that shows significant in vitro and in vivo inhibitory activity against MDA-MB-231 cells with eight to ten-fold higher potency than curcumin. Here, we modified the &#945;-position (C-4 position)...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Der-Yen Lee, Yu-Chi Hou, Jai-Sing Yang, Hui-Yi Lin, Tsu-Yuan Chang, Kuo-Hsiung Lee, Sheng-Chu Kuo, Min-Tsang Hsieh
Format: Artigo
Jezik:Inglês
Izdano: MDPI AG 2020-01-01
Serija:Molecules
Teme:
curcuminoid derivatives
prodrug
colon cancer
breast cancer
active metabolites
Online dostop:https://www.mdpi.com/1420-3049/25/3/479
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki