Multiplexed Nanopore Sequencing of HLA-B Locus in Māori and Pacific Island Samples

The human leukocyte antigen (HLA) system encodes the human major histocompatibility complex (MHC). HLA-B is the most polymorphic gene in the MHC class I region and many HLA-B alleles have been associated with adverse drug reactions (ADRs) and disease susceptibility. The frequency of such HLA-B allel...

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Hauptverfasser: Kim N. T. Ton, Simone L. Cree, Sabine J. Gronert-Sum, Tony R. Merriman, Lisa K. Stamp, Martin A. Kennedy
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018-04-01
Schriftenreihe:Frontiers in Genetics
Schlagworte:
HLA-B
nanopore sequencing
Māori
Pacific Island
pharmacogenetics
Polynesian
Online Zugang:http://journal.frontiersin.org/article/10.3389/fgene.2018.00152/full
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