Effective and persistent antitumor activity of HER2-directed CAR-T cells against gastric cancer cells in vitro and xenotransplanted tumors in vivo

Abstract Human epidermal growth factor receptor 2 (HER2) proteins are overexpressed in a high proportion of gastric cancer (GC) cases and affect the maintenance of cancer stem cell (CSC) subpopulations, which are used as targets for the clinical treatment of patients with HER2-positive GC. Despite i...

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Detalhes bibliográficos
Main Authors: Yanjing Song, Chuan Tong, Yao Wang, Yunhe Gao, Hanren Dai, Yelei Guo, Xudong Zhao, Yi Wang, Zizheng Wang, Weidong Han, Lin Chen
Formato: Artigo
Idioma:Inglês
Publicado em: SpringerOpen 2017-03-01
Colecção:Protein & Cell
Assuntos:
chimeric antigen receptor
HER2
gastric cancer
cancer stem cell
CD137
immunotherapy
Acesso em linha:http://link.springer.com/article/10.1007/s13238-017-0384-8
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