Association Between a Variable Number Tandem Repeat Polymorphism Within the DAT1 Gene and the Mesolimbic Pathway in Parkinson's Disease

The loss of ventral striatal dopaminergic neurons in Parkinson's disease (PD) predicts an impact on the reward system. The ventrostriatal system is involved in motivational processing and its dysfunction may be related to non-motor symptoms such as depression and apathy. We previously documente...

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Main Authors: Stefan du Plessis, Minke Bekker, Chanelle Buckle, Matthijs Vink, Soraya Seedat, Soraya Bardien, Jonathan Carr, Shameemah Abrahams
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Neurology
Assuntos:
DAT1
SLC6A3
Parkinson's disease
monetary incentive delay
orbitofrontal cortex
ventral striatum
Acceso en liña:https://www.frontiersin.org/article/10.3389/fneur.2020.00982/full
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