Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis

Abstract Ectopic ceramide accumulation in insulin-responsive tissues contributes to the development of obesity and impairs insulin sensitivity. Moreover, pharmacological inhibition of serine palmitoyl transferase (SPT), the first enzyme essential for ceramide biosynthesis using myriocin in rodents r...

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Главные авторы: Ying Li, Chad Lamar Talbot, Bhawna Chandravanshi, Alec Ksiazek, Ayushi Sood, Kamrul Hasan Chowdhury, J. Alan Maschek, James Cox, Adhini Kuppuswamy Satheesh Babu, Henry A. Paz, Pon Velayutham Anandh Babu, David K. Meyerholz, Umesh D. Wankhade, William Holland, E. Shyong Tai, Scott A. Summers, Bhagirath Chaurasia
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Portfolio 2022-05-01
Серии:Scientific Reports
Online-ссылка:https://doi.org/10.1038/s41598-022-11219-3
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