FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ.

Nimustine (ACNU) and temozolomide (TMZ) are DNA alkylating agents which are commonly used in chemotherapy for glioblastomas. ACNU is a DNA cross-linking agent and TMZ is a methylating agent. The therapeutic efficacy of these agents is limited by the development of resistance. In this work, the role...

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Detalhes bibliográficos
Principais autores: Natsuko Kondo, Akihisa Takahashi, Eiichiro Mori, Taichi Noda, Małgorzata Z Zdzienicka, Larry H Thompson, Thomas Helleday, Minoru Suzuki, Yuko Kinashi, Shinichiro Masunaga, Koji Ono, Masatoshi Hasegawa, Takeo Ohnishi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2011-05-01
coleção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3090409?pdf=render
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