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A chemical analog of curcumin as an improved inhibitor of amyloid Abeta oligomerization.

Amyloid-like plaques are characteristic lesions defining the neuropathology of Alzheimer's disease (AD). The size and density of these plaques are closely associated with cognitive decline. To combat this disease, the few therapies that are available rely on drugs that increase neurotransmissio...

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Bibliografiske detaljer
Main Authors: Robert A Orlando, Amanda M Gonzales, Robert E Royer, Lorraine M Deck, David L Vander Jagt
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2012-01-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC3307704?pdf=render
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