Genetic Deletion of Prostacyclin IP Receptor Exacerbates Transient Global Cerebral Ischemia in Aging Mice

Transient global cerebral ischemia causes delayed neuronal death in the hippocampal CA1 region. It also induces an up regulation of cyclooxygenase 2 (COX-2), which generates several metabolites of arachidonic acid, known as prostanoids, including Prostaglandin I2 (PGI2). The present study investigat...

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Détails bibliographiques
Auteurs principaux: Hania Shakil, Sofiyan Saleem
Format: Artigo
Langue:Inglês
Publié: MDPI AG 2013-07-01
Collection:Brain Sciences
Sujets:
global cerebral ischemia
aging
cognitive deficit
prostaglandin I2
mouse
Accès en ligne:http://www.mdpi.com/2076-3425/3/3/1095
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