EAAC1 Gene Deletion Alters Zinc Homeostasis and Exacerbates Neuronal Injury after Transient Cerebral Ischemia

EAAC1 is a neuronal glutamate and cysteine transporter. EAAC1 uptake of cysteine provides substrate for neuronal glutathione synthesis, which plays a key role in both antioxidant defenses and intracellular zinc binding. Here we evaluated the role of EAAC1 in neuronal resistance to ischemia. EAAC1(−/...

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Publicado no:J Neurosci
Main Authors: Won, Seok Joon, Yoo, Byung Hoon, Brennan, Angela M., Shin, Byung Seop, Kauppinen, Tiina M., Berman, Ari E., Swanson, Raymond A., Suh, Sang Won
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633677/
https://ncbi.nlm.nih.gov/pubmed/21084597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2084-10.2010
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