A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression.

Hematopoietic progenitors undergo differentiation while navigating several cell division cycles, but it is unknown whether these two processes are coupled. We addressed this question by studying erythropoiesis in mouse fetal liver in vivo. We found that the initial upregulation of cell surface CD71...

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Bibliographic Details
Main Authors: Ramona Pop, Jeffrey R Shearstone, Qichang Shen, Ying Liu, Kelly Hallstrom, Miroslav Koulnis, Joost Gribnau, Merav Socolovsky
Format: Artigo
Language:Inglês
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20877475/?tool=EBI
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