Agonistic nanobodies and antibodies to human VISTA

The V-domain Ig Suppressor of T-cell Activation (VISTA) is an immune checkpoint regulator that suppresses immune responses and is readily expressed on human and murine myeloid cells and T cells. This immunosuppressive pathway can be activated using VISTA agonists. Here, we report the development of...

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Bibliographische Detailangaben
Hauptverfasser: Yu-Heng Vivian Ma, Amanda Sparkes, Ema Romão, Shrayasee Saha, Jean Gariépy
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis Group 2021-01-01
Schriftenreihe:mAbs
Schlagworte:
VISTA
monoclonal antibodies
nanobodies
agonistic
anti-inflammatory
psoriasis
Online Zugang:https://www.tandfonline.com/doi/10.1080/19420862.2021.2003281
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