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Identification of New DR5 Agonistic Nanobodies and Generation of Multivalent Nanobody Constructs for Cancer Treatment

Current cancer therapeutics suffer from a lack of specificity in targeting tumor cells and cause severe side effects. Therefore, the design of highly specialized drugs comprising antibody derivatives inducing apoptosis in targeted cancer cells is considered to be a promising strategy. Drugs acting o...

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Publicat a:Int J Mol Sci
Autors principals: Sadeghnezhad, Golnaz, Romão, Ema, Bernedo-Navarro, Robert, Massa, Sam, Khajeh, Khosro, Muyldermans, Serge, Hassania, Sadegh
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6801735/
https://ncbi.nlm.nih.gov/pubmed/31569768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20194818
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