Mechanisms of action of metformin in type 2 diabetes: Effects on mitochondria and leukocyte-endothelium interactions

Type 2 diabetes (T2D) is a very prevalent, multisystemic, chronic metabolic disorder closely related to atherosclerosis and cardiovascular diseases. It is characterised by mitochondrial dysfunction and the presence of oxidative stress. Metformin is one of the safest and most effective anti-hyperglyc...

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Main Authors: Nadezda Apostolova, Francesca Iannantuoni, Aleksandra Gruevska, Jordi Muntane, Milagros Rocha, Victor M. Victor
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2020-07-01
Serija:Redox Biology
Teme:
Type 2 diabetes
Metformin
Oxidative stress
Pathophysiology
Treatment
Atherosclerosis
Online dostop:http://www.sciencedirect.com/science/article/pii/S2213231719315393
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