Mechanisms of action of metformin in type 2 diabetes: Effects on mitochondria and leukocyte-endothelium interactions

Type 2 diabetes (T2D) is a very prevalent, multisystemic, chronic metabolic disorder closely related to atherosclerosis and cardiovascular diseases. It is characterised by mitochondrial dysfunction and the presence of oxidative stress. Metformin is one of the safest and most effective anti-hyperglyc...

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Bibliographic Details
Main Authors: Nadezda Apostolova, Francesca Iannantuoni, Aleksandra Gruevska, Jordi Muntane, Milagros Rocha, Victor M. Victor
Format: Artigo
Language:Inglês
Published: Elsevier 2020-07-01
Series:Redox Biology
Subjects:
Type 2 diabetes
Metformin
Oxidative stress
Pathophysiology
Treatment
Atherosclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231719315393
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