Mechanisms of action of metformin in type 2 diabetes: Effects on mitochondria and leukocyte-endothelium interactions

Type 2 diabetes (T2D) is a very prevalent, multisystemic, chronic metabolic disorder closely related to atherosclerosis and cardiovascular diseases. It is characterised by mitochondrial dysfunction and the presence of oxidative stress. Metformin is one of the safest and most effective anti-hyperglyc...

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Главные авторы: Nadezda Apostolova, Francesca Iannantuoni, Aleksandra Gruevska, Jordi Muntane, Milagros Rocha, Victor M. Victor
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2020-07-01
Серии:Redox Biology
Предметы:
Type 2 diabetes
Metformin
Oxidative stress
Pathophysiology
Treatment
Atherosclerosis
Online-ссылка:http://www.sciencedirect.com/science/article/pii/S2213231719315393
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