Non-ionizing 405 nm Light as a Potential Bactericidal Technology for Platelet Safety: Evaluation of in vitro Bacterial Inactivation and in vivo Platelet Recovery in Severe Combined Immunodeficient Mice

Bacterial contamination of ex vivo stored platelets is a cause of transfusion-transmitted infection. Violet-blue 405 nm light has recently demonstrated efficacy in reducing the bacterial burden in blood plasma, and its operational benefits such as non-ionizing nature, penetrability, and non-requirem...

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Bibliographic Details
Main Authors: Michelle Maclean, Monique P. Gelderman, Sandhya Kulkarni, Rachael M. Tomb, Caitlin F. Stewart, John G. Anderson, Scott J. MacGregor, Chintamani D. Atreya
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Medicine
Subjects:
405 nm light
bacteria
platelets
inactivation
violet-blue light
pathogen reduction
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2019.00331/full
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