Antiepileptic Drugs Elevate Astrocytic Kir4.1 Expression in the Rat Limbic Region

Inwardly rectifying potassium (Kir) channel subunits Kir4.1 are specifically expressed in astrocytes and regulate neuronal excitability by mediating spatial potassium buffering. In addition, it is now known that astrocytic Kir4.1 channels are closely involved in the pathogenesis of epilepsy. Here, t...

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Autors principals: Takahiro Mukai, Masato Kinboshi, Yuki Nagao, Saki Shimizu, Asuka Ono, Yoshihisa Sakagami, Aoi Okuda, Megumi Fujimoto, Hidefumi Ito, Akio Ikeda, Yukihiro Ohno
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018-08-01
Col·lecció:Frontiers in Pharmacology
Matèries:
astrocytes
Kir4.1 channels
epilepsy
antiepileptic drugs
amygdala
Accés en línia:https://www.frontiersin.org/article/10.3389/fphar.2018.00845/full
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