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Radiation therapy and anti-tumor immunity: exposing immunogenic mutations to the immune system

Abstract The expression of antigens that are recognized by self-reactive T cells is essential for immune-mediated tumor rejection by immune checkpoint blockade (ICB) therapy. Growing evidence suggests that mutation-associated neoantigens drive ICB responses in tumors with high mutational burden. In...

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Bibliografiske detaljer
Main Authors: Claire Lhuillier, Nils-Petter Rudqvist, Olivier Elemento, Silvia C. Formenti, Sandra Demaria
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2019-06-01
Serier:Genome Medicine
Online adgang:http://link.springer.com/article/10.1186/s13073-019-0653-7
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