HCT116 colorectal liver metastases exacerbate muscle wasting in a mouse model for the study of colorectal cancer cachexia

Colorectal cancer (CRC) is often accompanied by formation of liver metastases (LM) and skeletal muscle wasting, i.e. cachexia. Despite affecting the majority of CRC patients, cachexia remains underserved, understudied and uncured. Animal models for the study of CRC-induced cachexia, in particular mo...

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Главные авторы: Joshua R. Huot, Leah J. Novinger, Fabrizio Pin, Andrea Bonetto
Формат: Artigo
Язык:Inglês
Опубликовано: The Company of Biologists 2020-01-01
Серии:Disease Models & Mechanisms
Предметы:
colorectal cancer
liver metastases
hct116
cachexia
stat3
skeletal muscle
Online-ссылка:http://dmm.biologists.org/content/13/1/dmm043166
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