ACVR2B antagonism as a countermeasure to multi‐organ perturbations in metastatic colorectal cancer cachexia

BACKGROUND: Advanced colorectal cancer (CRC) is often accompanied by the development of liver metastases, as well as cachexia, a multi‐organ co‐morbidity primarily affecting skeletal (SKM) and cardiac muscles. Activin receptor type 2B (ACVR2B) signalling is known to cause SKM wasting, and its inhibi...

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Publicat a:J Cachexia Sarcopenia Muscle
Autors principals: Huot, Joshua R., Pin, Fabrizio, Narasimhan, Ashok, Novinger, Leah J., Keith, Austin S., Zimmers, Teresa A., Willis, Monte S., Bonetto, Andrea
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749603/
https://ncbi.nlm.nih.gov/pubmed/33200567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcsm.12642
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